Using Mendelian Randomization to assess the causal association of polycystic ovary syndrome with adverse pregnancy and obstetric outcomes

Polycystic ovary syndrome (PCOS) is a very common hormonal condition and affects up to 10 % of women in the reproductive age group. PCOS is associated with conditions such as diabetes, high blood pressure, a higher risk of cancer, and adverse outcomes in pregnancy. However, the impact of PCOS on pregnancy and complications during childbirth is not well understood, especially in the south Asian population. The Born in Bradford cohort will provide a unique opportunity to study the Effect of PCOS on pregnancy and complications in women with PCOS. We propose a two-step project. In the first step, we will identify women diagnosed with PCOS in the Born in Bradford cohort and study the adverse outcomes during pregnancy. We will specifically look at maternal outcomes such as hypertension and diabetes during pregnancy, infant birth outcomes (like Live birth, miscarriage, and stillbirth), and low or high birth weight. The second step will look at all the women in the Born in Bradford cohort to see if the genetic risks of PCOS increase the risk of these adverse pregnancy outcomes in women and infants.
This will increase our understanding of the effect of PCOS on these important maternal and infant conditions and will guide us to make changes in clinical practice if necessary.