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Born in Bradford is part of the LIFECYCLE project. The overarching concept of The LifeCycle Project is innovative research on the role of novel integrated markers of early-life stressors that influence health across the life cycle using an open and long-term network of European cohorts that started during pregnancy or childhood.
The major ground-breaking perspective of LifeCycle is to establish a sustainable European Pregnancy and Child Cohort by bringing together existing and successful cohorts into a new and open EU CHILD Cohort Network. We will then use this unique network to identify new markers of integrated early-life stressors related to health trajectories throughout the full life cycle and translate our findings into policy recommendations for stratified and targeted prevention strategies focused on parents and young children. LifeCycle will lead to major progress in developing new perspectives on early-life prevention strategies.
1. Establish a new, open and long-term multidisciplinary EU Child Cohort Network.
2. Enrich the EU CHILD Cohort Network with novel integrated data on early-life stressors.
3. Identify early-life stressors influencing developmental adaptations and risk of non communicable disesases during the life cycle.
4. Develop analytical methods for causal inference and longitudinal modelling in observational cohort studies.
5. Identify DNA methylation markers mediating the relations of early-life stressors and health trajectories.
6. Identify interventions on early-life stressors that affect life course health and develop recommendations.
7. Generate personalized risk prediction models in eHealth applications based on early-life stressors.