Urban exposome and blood pressure trajectories from birth to adolescence

With 68% of the world population projected to live in urban areas by 2050, there is a growing interest in understanding how urban exposures can affect health. The urban exposome encompasses all environmental exposures related to the urban environment, such as air pollution, noise, traffic, natural spaces, built environment, light pollution and climatic factors. According to the Developmental Origins of Health and Disease (DOHaD) approach, exposures occurring in utero and during early life have the potential to affect diseases later in life, including metabolic and cardiovascular diseases. Some urban exposures have been previously examined separately with regard to childhood blood pressure but few studies have looked at the effects of urban exposome (Warembourg et al. 2021, Soares et al. 2024)
We will perform an individual participant data meta-analysis using data from pregnancy cohorts to assess the associations, using an exposome approach, of a range of urban environmental exposures with systolic and diastolic blood pressure from birth to adolescence.