Vrijheid, Martinea; Basagaña Xaviera; Gonzalez Juan; Jaddoe Vincent W. V.d,e; Jensen Genonf; Keun Hector; McEachan, Rosemary ; Porcel Joanaa–c; Siroux Valeriei; Swertz Morris A.j,k; Thomsen Cathrinel; Aasvang Gunn Maritl; Andrušaitytė Sandram; Angeli Karinen; Avraam Demetriso; Ballester Ferranb; Burton Paulo; Bustamante Marionaa; Casas Maribela; Chatzi Ledar; Chevrier Céciles; Cingotti Natachaf; Conti Davidr; Crépet Amélien; Dadvand Payama; Duijts Liesbethd; van Enckevort Esther; Esplugues Anab; Fossati Serenaa; Garlantezec Ronant; Gómez Roig María Doloresu; Grazuleviciene Reginam; Gützkow Kristine B.l; Guxens, Mònicaa; Haakma Sidoj; Hessel Ellen V. S; Hoyles Lesleyz; Hyde Eleanorjk; Klanova Janaaa; van Klaveren Jacob Dy; Kortenkamp Andreasbb; Le Brusquet Laurentcc; Leenen Ivonnef; Lertxundi Aitana; Lertxundi Nereadd; Lionis Christosff; Llop Sabrinab; Lopez-Espinosa, Maria-Joseb; Lyon-Caen, Sarah; Maitre Leaa; Mason Dan; Mathy Sandrinegg; Mazarico Edurneu; Nawrot Timhh; Nieuwenhuijsen Marka; Ortiz Rodneya; Pedersen Mariejj; Perelló Josepkk; Pérez-Cruz Míriamu; Philippat Clairei; Piler Pavelaa; Pizzi Costanzall; Quentin Joanei; Richiardi Lorenzoll; Rodriguez Adriankk; Roumeliotaki Theanoff; Sabin Capote José Manuelkk; Santiago Leonardokk; Santos Susanade; Siskos Alexandros ; Strandberg-Larsen, Katrinejj; Stratakis Nikosar; Sunyer Jordia; Tenenhaus Arthurcc; Vafeiadi Marinaff; Wilson Rebecca ; Wright John; Yang Tiffany; Slama Remyi
Early life stages are vulnerable to environmental hazards and present important windows of opportunity for lifelong disease prevention. This makes early life a relevant starting point for exposome studies. The Advancing Tools for Human Early Lifecourse Exposome Research and Translation (ATHLETE) project aims to develop a toolbox of exposome tools and a Europe-wide exposome cohort that will be used to systematically quantify the effects of a wide range of community- and individual-level environmental risk factors on mental, cardiometabolic, and respiratory health outcomes and associated biological pathways, longitudinally from early pregnancy through to adolescence. Exposome tool and data development include as follows: (1) a findable, accessible, interoperable, reusable (FAIR) data infrastructure for early life exposome cohort data, including 16 prospective birth cohorts in 11 European countries; (2) targeted and nontargeted approaches to measure a wide range of environmental exposures (urban, chemical, physical, behavioral, social); (3) advanced statistical and toxicological strategies to analyze complex multidimensional exposome data; (4) estimation of associations between the exposome and early organ development, health trajectories, and biological (metagenomic, metabolomic, epigenetic, aging, and stress) pathways; (5) intervention strategies to improve early life urban and chemical exposomes, co-produced with local communities; and (6) child health impacts and associated costs related to the exposome. Data, tools, and results will be assembled in an openly accessible toolbox, which will provide great opportunities for researchers, policymakers, and other stakeholders, beyond the duration of the project. ATHLETE’s results will help to better understand and prevent health damage from environmental exposures and their mixtures from the earliest parts of the life course onward.
